雷沙吉兰对小鼠肝和脑组织中单胺氧化酶活性的影响

Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues

摘要:

目的：考察腹腔注射雷沙吉兰对小鼠中肝和脑单胺氧化酶（monoamine oxidase，MAO）活性的抑制作用。方法：采用紫外分光光度法，分别测定低温差速离心法提取小鼠肝和脑组织中的MAO-A和MAO-B活性。结果：雷沙吉兰对MAO-B活性的抑制作用明显强于MAO-A活性；在脑中抑制作用显著比在肝脏中强。结论：雷沙吉兰对小鼠脑内MAO-B活性具有较高的选择性抑制作用。

Abstract:

Objective：To investigate the inhibition of rasagiline on monoamine oxidase（MAO） in mouse liver and brain tissues. Methods：After being extracted by differential centrifugation，activities of MAO-A and MAO-B in mouse liver and brain tissues were determined by UV spectrophotometry respectively. Results：Inhibition effect of rasagiline was stronger on MAO-B than on MAO-A and inhibition effect of rasagiline was stronger in the brain than in the liver. Conclusion：Rasagiline exerts selective inhibition effects on MAO-B in mouse liver and brain tissues.