肺癌患者常见症状群及与生存质量的相关性研究

Symptom cluster and its relationship with life quality of patients with lung cancer

摘要:

目的：探讨肺癌患者乏力、失眠、疼痛和苦恼的发生率及严重程度，并检测以上4种症状是否以症状群的形式影响患者的病情结果。方法：采用横断面的研究方法，应用安德森症状评估量表及癌症病人生命质量测定量表体系中的肺癌量表对384名住院肺癌患者进行问卷调查。结果：失眠、乏力、疼痛和苦恼各症状间具有显著的内部相关性（r=0.474～0.716，P＜0.01），其中9.1%（n=35）和21.1%（n=81）的患者表示在治疗过程中出现过上述症状中的2种或3种症状，62.8%（n=241）的肺癌患者同时遭受到4种症状的困扰；症状群与生存质量各维度得分及总分均呈负相关性。结论：失眠、乏力、疼痛和苦恼为肺癌患者疾病发展轨迹过程中出现频率最高、程度最重的4种症状，且常常以症状群的形式影响患者的生存质量。

Abstract:

Objective：To explore the incidence and severity of fatigue，disturbed sleep，pain and distress and to examine whether the above four symptoms occur in symptom cluster during the trajectory of disease. Methods：This cross-sectional study design was as－sessed by M.D. Anderson symptom inventory and quality of life instruments for cancer patients-lung cancer. Three-hundred and eighty four individuals were involved in the survey. Results：There were significant inter-correlations among fatigue，disturbed sleep，pain and distress（r=0.474-0.716，P＜0.01）. About 9.1%（n=35） and 21.1%（n=81） patients reported co-occurrence of any two and any three symptoms of fatigue，disturbed sleep，pain and distress and 62.8%（n=241） patients reported co-occurrence of all four symptoms. Negative relationship was found between the top four symptoms and subscale/total scores of life quality. Conclusions：Fatigue，disturbed sleep，pain and distress are the most common and severe symptoms of patients with lung cancer，which exert negatively effects on life quality through symptom cluster.