趋化因子MIP-1α、MIP-1β、MCP-1在自身免疫性甲状腺疾病中的表达及意义

Expressions and significances of chemokines MIP-1α，MIP-1β and MCP-1 in autoimmune thyroid disease

摘要:

目的：探讨趋化因子巨噬细胞炎性蛋白-1α（macrophage inflammatory protein-1α，MIP-1α）、巨噬细胞炎性蛋白-1β（macrophage inflammatory protein-1β，MIP-1β）和单核细胞趋化蛋白-1（monocyte chemoattractant protein-1，MCP-1）在自身免疫性甲状腺疾病发生发展中的作用。方法：应用免疫组化方法观察MIP-1α、MIP-1β和MCP-1在44例Graves病（Graves disease，GD）和19例桥本甲状腺炎（hashimoto thyroiditis，HT）、14例甲状腺腺瘤、10例结节性甲状腺肿及8例正常甲状腺组织（取自良性腺瘤周围）中的表达情况。结果：MIP-1α、MIP-1β、MCP-1蛋白定位于甲状腺滤泡上皮细胞质，其在GD、TH组织中的表达阳性率及总评分显著高于结节性甲状腺肿及正常甲状腺组织。结论：MIP-1α、MIP-1β、MCP-1可能参与了自身免疫性甲状腺疾病的发生发展，有可能作为自身免疫性甲状腺疾病监测和治疗的新靶点。

Abstract:

Objective：To explore the role and development of chemokines macrophage inflammatory protein-1α（MIP-1α），macro-phage inflammatory protein-1β（MIP-1β） and monocyte chemoattractant protein-1（MCP-1） in adults with autoimmune thyroiditis. Methods：Totally 44 cases of Graves disease（GD），19 cases of hashimoto thyroiditis（HT），14 cases of thyroid adenoma，10 cases of multinodular goiter and 8 cases of surrounding normal tissues were collected. Expressions of chemokines MIP-1α，MIP-1β and MCP-1 were determined by immunehistochemical method. Results：Chemokines MIP-1α，MIP-1β and MCP-1 were located in the cytoplasm of the thyroid follicular epithelial cells. Expression levels and scores of chemokines MIP-1α，MIP-1β and MCP-1 were significantly higher in GD and HT than in multinodular goiter and thyroid normal tissues. Conclusions：Chemokines MIP-1α，MIP-1β and MCP-1 may participate in the development of the autoimmune thyroid diseases and may become new targets of monitoring and treatment of autoimmune thyroid diseases.