成纤维细胞生长因子19和成纤维细胞生长因子受体4在食管鳞癌中的表达及其意义

Expressions of fibroblast growth factor 19 and fibroblast growth factor receptor 4 in esophageal squamous carcinoma and their significances

摘要:

目的：探讨成纤维细胞生长因子19（fibroblast growth factor 19，ＦＧＦ１９）和成纤维细胞生长因子受体4（fibroblast growth factor receptor 4，ＦＧＦＲ４）在食管鳞癌中的表达及其是否存在相关性。方法：利用免疫组织化学法检测我院2009-2012年间34例食管鳞癌术后病理标本中肿瘤组织和正常食管组织中FGF19和FGFR4 蛋白的表达，并进行统计学分析。结果：FGF19和FGFR4在人类食管鳞癌组织中均高表达（P=0.000，P=0.000），FGFR4和FGF19在食管鳞癌中的表达与淋巴结转移（rs=0.401，P=0.019；rs=0.404，P=0.018）和病理分期（rs=0.495，P=0.003；rs=0.439，P=0.009）呈正相关，并且在食管鳞癌中FGFR4与FGF19的表达呈正直线相关（rs=0.483；P=0.004）。结论：FGF19和FGFR4与食管鳞癌的发生有关，并参与其侵袭转移过程。

Abstract:

Objective：To investigate the expressions of fibroblast growth factor 19（FGF19） and fibroblast growth factor receptor 4 （FGFR4） in esophageal squamous carcinoma and normal esophageal tissues and their correlation. Methods：Immunohistochemical method was used to detect the FGF19 and FGFR4 protein expressions in 34 postoperative pathological specimens of esophageal squa－mous carcinoma in patients in our hospital from 2009-2012 and normal esophageal tissues. Statistics analysis was made after the de－tection. Results：FGF19 and FGFR4 expressions were high in esophageal squamous carcinoma（P=0.000，P=0.000）. There was a posi－tive linear correlation between expressions of FGFR4 and FGF19 and lymph node metastasis（rs=0.401，P=0.019；rs=0.404，P=0.018） and pathological stage（rs=0.495，P=0.003；rs=0.439，P=0.009） in esophageal squamous carcinoma. Expressions of FGFR4 and FGF19 were in a positive linear correlation in the disease. Conclusions：FGF19 and FGFR4 proteins are correlated with esophageal squamous carcinoma and they participate in the process of invasion and metastasis.