Ezrin蛋白表达与鼻咽癌远处转移的相关性研究

Relationship between expressions of Ezrin protein and distant metastasis of nasopharyngeal carcinoma

摘要:

目的：研究Ezrin蛋白在鼻咽癌（nasopharyngeal carcinoma，NPC）组织中的表达及其与NPC远处转移的相关性。方法：收集76例NPC患者的临床资料及鼻咽部瘤体活检组织蜡块。采用免疫组化SP法检测标本中Ezrin蛋白的表达。用Kaplan-Meier法计算转移风险，用logistic回归分析判别NPC远处转移的危险因素。结果：Ezrin蛋白阳性表达率为 63.2%（48/76），其表达与远处转移关系密切（P＜0.05）。NPC远处转移的危险因素是临床分期、颈淋巴结转移、Ezrin蛋白阳性表达（P＜0.05）。Ezrin蛋白为阳性表达者远处转移风险更高（P＜0.05）。结论：Ezrin蛋白阳性表达与NPC转移明显相关，可作为NPC远处转移的预测指标。

Abstract:

Objective：To explore the relationship between expressions of Ezrin protein and distant metastasis of nasopharyngeal carci－noma（NPC）. Methods：Clinical data and biopsy samples of 76 patients with NPC were collected. Ezrin protein expressions were de－tected by immunohistochemical SP method. Kaplan-Meier method was used to calculate the metastasis risk and logistic regression analysis was applied to judge the risk factors of NPC distant metastasis. Results：Positive expression rate of Ezrin protein was 63.2% （48/76），which was positively correlated with lymph node metastasis and distant metastasis（P<0.05）. Logistic regression analysis showed that risk factors of distant metastasis in NPC included T stage，cervical lymph node metastasis and positive expression of Ezrin （P<0.05）. NPC patients with Ezrin positive expressions had higher metastasis risk（P<0.05）. Conclusions：Ezrin protein positive ex－pression is significantly related with metastasis of NPC and can be used as predictor of NPC distant metastasis.