结直肠癌中KAI1/CD82的表达及其与临床病理的联系

Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics

摘要:

目的：探讨结直肠癌组织中KAI1/CD82的表达及其与肿瘤转移的关系。方法：应用组织芯片和免疫组织化学技术检测233例结直肠癌组织中KAI1/CD82的表达。结果：KAI1/CD82在结直肠癌组织中阳性率为51.5%，其表达与患者的性别、年龄、浸润深度、淋巴结转移无关，而与肿瘤的分化程度、Dukes分期有关（P<0.05）。二元Logistic回归前进法显示：分化是影响KAI1/CD82表达最显著因素[Exp（b）=0.431，P=0.038]。其次是Dukes分期[Exp（b）=0.363，P=0.043]。结直肠癌中KAI1/CD82在分化低的肿瘤和Dukes D期肿瘤表达降低。结论：KAI1/CD82在结直肠癌组织中的表达缺失与肿瘤的分化程度、分期密切相关，有望成为判断结直肠癌预后的新标志。

Abstract:

Objective：To investigate expressions of KAI1/CD82 in colorectal carcinoma and their correlation with the metastasis of col－orectal carcinoma. Methods：Tissue microarray and immunohistochemistry were used to detect expressions of KAI1/CD82 in 233 cases of colorectal carcinoma. Results：Positive rate of KAI1/CD82 expression in colorectal carcinoma was 51.5%. Expressions of KAI1/CD82 were not correlated with patients’ sex，age，depth of infiltration and lymphnode metastasis，but were correlated with differentia－tion degrees and Dukes stages（P<0.05）. Forward stepwise binary Logistic regression revealed that differentiation was the most signifi－cant influencing factor of KAI1/CD82 expression，Exp（b）=0.431，P=0.038，followed by Dukes stage，Exp（b）=0.363，P=0.043. Expres－sions of KAI1/CD82 were decreased in colorectal carcinoma with poor differentiation and at Dukes D stage. Conclusions：Expressions of KAI1/CD82 are closely correlated with differentiation degrees and stages，which are expected to become a new target for tumor prognosis.