Objective:To observe whether telephone guidance by specialists can improve the efficacy of the treatment for stable coronary heart disease or can reduce incidence of major cardiovascular events. Methods:Totally 200 patients with stable coronary heart disease were divided into telephone guidance group(n=100) and control group(n=100). Patients in telephone guidance group re-ceived the specialists’ telephone guidance every 2 months. Indicators included the compliance of healthy life style,rate of taking cura-tive standard medicines,major cardiovascular events and patients’satisfaction degree. Results:Patient’s compliance of healthy life style,rate of taking curative standard medicines and patients’satisfaction degree were all higher in telephone guidance group than in control group(P<0.05),but incidences of major cardiovascular events(myocardial infarction,readmission,revascularization of coro-nary artery,cardiac death) were lower in telephone guidance group than in control group(P<0.05). Conclusions:Telephone guidance by specialists can improve the efficacy of the treatment for stable coronary heart disease and reduce incidence of major cardiovascular events.