孕前和孕早期叶酸补充与双胎妊娠率的Meta分析

Effects of periconceptional folic acid supplementation on incidences of twin pregnancy：a Meta analysis

摘要:

目的：本文旨在系统评价孕前和孕早期补充叶酸对双胎妊娠的作用。方法：系统收集1966-2012年来自PubMed/Med－line、EMBASE、OVID、Cochrane Central Register of Clinical Trials、Google Scholarism、CNKI、维普、万方数据库关于孕前和孕早期补充叶酸的相关文献，并根据预先制定的纳入与排除标准筛选文献，严格评价纳入文献质量，提取数据，RevMan 5.2.1软件进行Meta分析。结果：纳入3篇随机对照试验，Meta分析结果示孕前和孕早期补充叶酸与未补充相比双胎妊娠率（RR=1.40，95%CI=0.93~2.11），双卵双生率（RR=1.27，95%CI=0.61~2.67）与单卵双生率（RR=0.91，95%CI=0.68~1.21）的差异均无统计学意义。结论：孕前和孕早期补充叶酸与未补充相比，没有提高双胎妊娠率。

Abstract:

Objective：To use Meta analysis to assess the effects of folic acid supplementation before and during early pregnancy on twin pregnancy. Methods：Literatures associated with periconceptional folic acid supplementation between 1966 and 2012 were col－lected systematically from PubMed/Medline，EMBASE，OVID，Cochrane Central Register of Clinical Trials，Google scholarism，CNKI，VIP，Wanfang databases，then were screened according to the pre-established inclusion and exclusion standards. Quality was evaluat－ed strictly. Data were extracted and Meta analysis was conducted using RevMan 5.2.1 software. Results：Three randomized controlled trials（RCTs） were included. Differences in twin pregnancy incidences（RR=1.40，95%CI=0.93 to 2.11），dizygotic incidences（RR=1.27，95%CI=0.61 to 2.67） and monozygotic incidences（RR=0.91，95%CI=0.68 to 1.21） were of no statistically significant between group with folic acid supplementation before and during early pregnancy and control group. Conclusion：Folic acid supplementation before and during early pregnancy can not increase incidences of twin pregnancy.