Notch1在先兆子痫胎盘组织中的表达
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Expression of Notch1 in pre-eclampsia complicated placentas
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    摘要:

    目的:探讨Notch信号通路成员Notch1在人类先兆子痫发生机制中的作用。方法:获取正常妊娠胎盘组织和先兆子痫胎盘组织,分别采用real-time PCR法、Western blot法、免疫组织化学法检测两种胎盘组织中Notch1 mRNA、蛋白表达及其分布水平。结果:Notch1在两种胎盘组织中均有表达,且主要集中在细胞膜上表达。Notch1在先兆子痫胎盘组织(实验组)的表达水平明显低于正常胎盘组织(对照组)(P<0.05)。结论:推测Notch1可通过Notch信号通路介导胎盘的血管发生、血管形成,影响胚泡滋养层细胞血管内的侵袭过程,其表达下调与先兆子痫的发生有关。

    Abstract:

    Objective:To explore the role of the Notch signaling members Notch1 in the mechanism of human pre-eclampsia. Methods:Placental tissues of normal pregnancy and pre-eclampsia were obtained respectively. Real-time PCR,Western blot and immunohisto-chemical method were used to detect the distribution and expression levels of Notch1 mRNA and Notch1 protein in both placental tissues. Results:Notch1 was expressed in both placental tissues and expression was localized in the membrane. Expression levels of Notch1 in placental tissues of pre-eclampsia(experiment group) were significantly lower than those in placental tissues of normal pregnancy(control group)(P<0.05). Conclusions:Notch1 may mediate the occurrence and development of placental vasculogenesis and influence the endovascular invasion of embryonic cytotrophoblasts through the Notch signaling pathway and the reduced expres-sion level of Notch1 may be associated with the occurrence of pre-eclampsia.

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黄 静,孙大光,张 益,杨 柳,计 垣,杨继高,李 红. Notch1在先兆子痫胎盘组织中的表达[J].重庆医科大学学报,2013,(10):1159-1162

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  • 在线发布日期: 2013-10-31
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