Objective:To explore the clinical value of prenatal ultrasonic examination in screening out fetal malformations. Methods:Pregnant women’s ultrasonic examination results in 2012 were analyzed retrospectively. Detection rate,systemmatic distribu-tion and severity of fetal malformations were calculated. Results:A total of 32 667 pregnant women underwent ultrasonography. Detection rate of fetal malformations was 1.27%(414/32 667). Cardiovascular system malformation was most common(23.43%,97/414),followed by nervous system malformation(17.15%,71/414). Rate of serious deformations was 54.59%(226/414),most common in nervous system malformation(27.88%,63/226). Conclusions:Prenatal ultrasonic examination is of great clinical value in screen-ing out fetal malformation and reducing birth birth defects.