5 539例孕妇孕中期唐氏筛查结果分析

Analysis on results of prenatal screening for Down’ syndrome in the second trimester of pregnancy in 5 539 cases

摘要:

目的：分析兰州大学第一医院2009年到2012年5 539例孕妇孕中期唐氏筛查结果，试图找出高危孕妇的可能危险因素。方法：采用时间分辨法检测孕妇外周血中游离β绒毛膜促性腺激素和甲胎蛋白的浓度，配合孕妇的年龄、孕周、体质量等，应用专用软件计算出该孕妇的唐氏风险率。结果：筛查出唐氏高风险的孕妇238例，占4.30%；≥35岁组的筛出率最高，为17.69%。结论：扩大唐氏筛查的筛查范围，再配合产前诊断是减少唐氏儿出生的最有效手段。

Abstract:

Objective：To analyze results of prenatal screening for Down’ syndrome in the second trimester of pregnancy in 5 539 cases in the First Hospital of Lanzhou University from 2009 to 2012 and to identify the possible risk factors for high risk pregnant women. Methods：Serum alpha-fetoprotein and free-β human chorionic gonadotropin in pregnant women were detected based on the principal of time-resolved immunoflourometric assay. Risk of fetal Down’ syndrome was calculated by computer software taking into con－siderations of maternal age，gestational age，weight of pregnant women. Results：Among the 5 539 pregnant women，238 cases