肺癌精确放疗所致放射性肺炎相关因素分析

Analysis of factors associated with radiation pneumonitis induced by precise radiotherapy for lung cancer

摘要:

目的：探讨肺癌患者精确放疗所致放射性肺炎（radiation pneumonitis，RP）的相关因素。方法：回顾性分析115例行精确放疗肺癌患者的临床资料、放疗物理参数与≥2级RP之间的关系。结果：19例患者（16.52%）发生RP。单因素分析有统计学差异的相关因素为慢性阻塞性肺部疾病（chronic obstructive pulmonary disease，COPD）、糖尿病、肿瘤位置、放疗方式和计划靶体积（planning target volume，PTV），经logistic多元回归分析发现COPD和PTV为RP发生的独立危险因素（P<0.05）。结论：COPD和PTV是RP发生的独立危险因素，对此类患者应谨慎优选放疗计划。

Abstract:

Objective：To evaluate the related factors of radiation pneumonitis（RP） induced by precise radiotherapy for patients with lung cancer. Methods：Clinical data and radiation physical parameters of 115 patients with lung cancer who were treated with precise radiotherapy were retrospectively analyzed and relationship between radiation physical parameters and RP≥2 grades was explored.Results：Nineteen patients（16.52%） developed RP. Single factor analysis found that related factors with statistically significant differ－ences were chronic obstructive pulmonary disease（COPD），diabetes，tumor location，radiation way and planning target volume（PTV）. Results of multivariate logistic regression analysis showed that COPD and PTV were independent risk factors for RP（P<0.05）. Con－clusions：COPD and PTV are independent risk factors for RP. For these patients，radiotherapy planning should be careful optimized.