B群链球菌在孕妇及新生儿中的带菌调查及耐药性研究

Survey of drug resistance of group B streptococcus in the carrier of perinatal pregnant women and their newborns

摘要:

目的：观察B群链球菌（group B streptococcus,GBS)在孕妇及新生儿中的带菌状况及耐药性，为提高患者的疗效、母婴生活质量提供依据。方法：426例围产期孕妇以及分娩后428例新生儿进行样本采集，之后给予GBS细菌鉴定及药敏试验，记录鉴定及药敏试验结果。结果：426例围产期孕妇GBS检测阳性率为19.01%，明显高于新生儿的1.40%，差异有统计学意义（?字2=72.38，P=0.000）。GBS对氨苄青霉素以及先锋青霉素药物的敏感性100%，临床可用上述药物对其进行治疗，能够达到较为满意的治疗效果。结论：临床工作中应对围产期孕妇采取GBS检测，若确认感染，则应积极采取治疗措施，避免发生母婴传播现象以及出现早产、晚期流产等情况，提高围产期孕妇与新生儿生活质量。

Abstract:

Objective：To observe the carrier status and drug resistance of group B streptococci（GBS） in perinatal pregnant women and their newborns and to improve patients’ life quality. Methods：Totally 426 perinatal pregnant women and 428 newborns were selected in our hospital and were received GBS bacteria identification and drug sensitivity test. Results were recorded and analyzed. Results：Positive rate of 426 cases of perinatal pregnant GBS was 19.01%，significantly higher than that of newborn（1.40%），with statistically significant differences（ ?字2=72.38，P=0.000）. GBS showed 100% sensitivity to ampicillin and penicillin. Drugs mentioned above can be used in clinics to achieve satisfactory effects. Conclusions：GBS test should be employed in the clinical work. If infection confirmed，the active therapeutic measures should be tak－en to avoid mother-to-child transmission，premature delivery，late abortion and to improve the perinatal maternal and neonatal life quality.