成年人复发性阿弗他溃疡致病相关因素分析

Pathogenic factors of recurrent aphthous ulcer in adults

摘要:

目的：通过对复发性阿弗他溃疡（recurrent aphthous ulcer，RAU）的致病相关因素进行调查，筛选出该病的主要致病相关因素。方法：采用自编的《RAU致病因素调查问卷》进行调查，使用非条件 logistic回归分析对各个相关因素进行统计。结果：引入回归方程的相关高危因素为：消化系统慢性疾病、精神压力、喜吃辣食、家族史、便秘、指数、吸烟指数和喜吃酸食，后两者的回归系数＜０，OR值＜１。经Spearman秩相关分析，RAU的发生与吸烟指数呈负相关（rs=－0.170，P=0.000），与指数呈正相关（rs=0.133，P=0.000）。结论：引起RAU发生的危险因素由大到小为：消化系统慢性疾病、精神压力、喜吃辣食、家族史、便秘和指数；吸烟和喜吃酸食可能会减轻 RAU的发生。

Abstract:

Objective：To explore the main risk factors of recurrent aphthous ulcer（RAV） by investigating its pathogenic factors. Meth－ods：Using the self-made questionnaire of RAU’s risk factors to do the investigation. The high-risk factors of RAU were screened out from all correlative factors by non-conditional logistic regression analysis. Results：The high-risk factors including chronic digestive system disease，mental pressure，liking spicy food，family history，constipation，calculus index，smoking index and liking acidic food were introduced in the regression equation. OR values and regression coefficient of smoking index factor and liking acidic food fac－tor were less than 1 and 0，respectiuely（P＜0.05）. RAU and smoking index showed a negative correlation（rs=－0.170，P=0.000） while RAU and calculus index showed a positive correlation（rs=0.133，P=0.000） based on Spearman rank correlation analysis. Conclusions：These pathogenic factors from high-risk to low-risk were chronic digestive system disease，mental pressure，liking spicy food，family history，constipation and calculus index. Smoking and liking for acidic food may be the protective factors of RAU.