饮酒对精液质量影响的Meta分析

Effects of alcohol drinking on male sperm quality：a Meta analysis

摘要:

目的：探讨饮酒对男性精液质量具体指标的影响。方法：应用Meta分析方法对检索到的有关饮酒与男性精液质量的研究进行结果的综合定量分析。结果：共纳入6项研究对象为男性不育患者的对照研究，涉及精液的精子密度（sperm density，SD）、a+b级精子活力（sperm energy a+b，SEa+b）、精子畸形率（rate of teratospermia，RT）3个方面，经Meta分析，其合并效应值分别为均数差（mean difference，MD）MDSD=-1.81，95%可信区间（confidence interval，CI）=-4.68～1.06；MDSEa+b=-8.39，95%CI=-19.22～2.43，饮酒组与未饮酒组的SD与SEa+b差异无统计学意义；MDRT=7.20，95%CI=1.62～12.78，饮酒组与未饮酒组的RT差异有统计学意义（Z=2.53，P=0.01）。结论：饮酒是男性不育的危险因素，其主要危害是增高RT。

Abstract:

Objective：To explore the effect of alcohol drinking on male sperm quality. Methods：Literatures on the relationship between drinking and male sperm quality were reviewed by conducting Meta analysis. Results：Six controlled studies on alcohol drinking and male infertility were included. Three aspects including sperm density（SD），sperm energy a+b（SEa+b），rate of teratospermia（RT） were focused. Combined mean differences（MDs） were -1.81（95%CI＝-4.68 to 1.06） in SD and -8.39（95%CI＝-19.22 to 2.43） in SEa+b；the difference of SD and SEa+b between drinking and non-drinking was not statistically significant：MD was 7.20（95%CI＝1.62 to 12.78） in RT，the difference of RT between drinking and non-drinking were statistically significant in Meta analysis. Conclusions：Alcohol drinking is a risk factor for male infertility and its main harm was to increase the RT.