Ezrin在结直肠癌的表达及其临床病理意义的Meta分析

Ezrin expression and its clinicopathological significance in colorectal cancer：a Meta analysis

摘要:

目的：系统评价结直肠癌中埃兹蛋白（Ezrin）表达水平及其临床病理意义的关系。方法：计算机检索EBSCO平台系列数据库、OVID平台EBMR+Journals英文数据库、PubMed、万方数据库、中国期刊全文数据库（CNKI）以及重庆维普中文科技期刊全文数据库（VIP）等，研究文献通过设置的纳入与排除标准选定，评价质量及提取资料后采用Reman 5.0软件对数据库进行系统评价。结果：符合条件的文献有14篇，其中结直肠癌患者1 383例，对照组298例。Meta分析结果显示：（1）结直肠癌组及正常对照组中Ezrin的表达差异有统计学意义（OR=15.72，95％CI=10.56~23.41，P=0.000）；（2）Ezrin表达与淋巴结转移（OR=2.96，95％CI=1.69~5.19，P=0.000）、Dukes分期（OR=0.17，95％CI=0.08~0.37，P=0.000）、肿瘤浸润深度（OR=0.56，95％CI=0.36~0.85，P=0.007）、肿瘤分化程度（OR=0.37，95％CI=0.19~0.69，P=0.002）相关，与性别（OR=1.19，95％CI=0.89~1.58，P=0.240）、年龄（OR=1.15，95％CI=0.69~1.91，P=0.600）、肿瘤大小（OR=1.07，95％CI=0.66~1.73，P=0.790）无关。结论：Ezrin在结直肠癌中高表达，高表达的Ezrin可能在结直肠癌的侵袭、转移过程中起到重要作用。

Abstract:

Objective：To investigate the expression and clinicopathological significance of Ezrin protein in colorectal cancer with a sys－tematic review. Methods：Published studies were searched in EBSCO，EBMR+Journals，Pubmed，Wangfang databases，CNKI，VIP and quality of the included studies was assessed. Meta analysis of enrolled studies was performed by Reman 5.0 software. Results：Totally 14 studies were selected for this Meta analysis，including 1 383 colorectal caner cases and 298 normal controls. Results of Meta anal－ysis showed that ①There were significant differences in positive rate of Ezrin expression between colorectal cancer tissues and normal tissues（OR=15.72，95％CI=10.56 to 23.41，P=0.000）. ②Ezrin expression were associated with lymph node metastasis（OR=2.96，95％CI=1.69 to 5.19，P=0.000），Duke classification（OR=0.17，95％CI=0.08 to 0.37，P=0.000），infiltration depth（OR=0.56，95％CI=0.36 to 0.85，P=0.007），histological subtype（OR=0.37，95％CI=0.19 to 0.69，P=0.002） but not associated with sex（OR=1.19，95％CI=0.89 to 1.58，P=0.240），age（OR=1.15，95％CI=0.69 to 1.91，P=0.600），tumor length（OR=1.07，95％CI=0.66 to 1.73，P=0.790）. Conclusions：Expression of Ezrin in colorectal cancer is high. High expression of Ezrin may play an important role in metastasis of colorectal cancer.