黄芪注射液联合阿维A对小鼠银屑病模型的影响

Effects of Radix Astragali injection combined with Acitretin on psoriasis mice model

摘要:

目的：观察黄芪注射液联合阿维A对小鼠银屑病模型的影响。方法：研究黄芪注射液联合阿维A对小鼠阴道上皮有丝分裂、增殖细胞核抗原（proliferating cell nuclear antigen，PCNA）、尾部鳞片表皮颗粒层形成及血浆内皮素-1（endothelin-1，ET-1）的影响。结果：黄芪注射液联合阿维A对上述4个指标均有作用，与对照组比较，差异有统计学意义（P均＜0.001），其中对小鼠阴道上皮有丝分裂和PCNA有明显的抑制作用，对小鼠尾部表皮增厚和颗粒形成具有明显的促进作用，对ET-1具有明显的抑制作用。结论：黄芪注射液联合阿维A具有改善和逆转小鼠银屑病病理模型的作用，其机理可能与抑制表皮细胞过度增生和促进颗粒层形成有关，其作用可能是阻断多个发病环节。

Abstract:

Objective：To observe the therapeutic effects of Radix Astragali injection combined with Acitretin on psoriasis mice model. Methods：Effects of Radix Astragali injection combined with Acitretin on proliferation of vaginal epithelium，proliferating cell nu－clear antigen（PCNA） expression，differentiation of tail scale epidermis and plasma endothelin-1（ET-1） were assessed in mice model. Results：Radix Astragali injection combined with Acitretin had effects on all 4 indices mentioned above. Radix Astragali injection com－bined with Acitretin can significant inhibit vaginal epithelium proliferation，PCNA expression and plasma ET-1 as well as promote the differentiation of tail scale epidermis with statistical differences compared with those in control group（P<0.001）. Conclusions：Radix Astragali injection combined with Acitretin can improve and reverse psoriatic pathology model in mice，the mechanism of which may relate with the inhibition of epidermal cell over-proliferation and the promotion of granular layer formation. Its therapeutic effects may be explained by bloclking multiple pathogenetic linkages.