联合非创伤性检查评估肝纤维化的临床研究

Evaluation on hepatic fibrosis by joint non-invasive method

摘要:

目的：建立适合临床推广的联合非创伤性评估非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）肝纤维化程度的方法和评估体系。方法：104例非酒精性脂肪性肝纤维化患者行病理分期，并测定肝纤维化相关标志物、金属蛋白酶1组织抑制剂（tissue inhibitors of matrix metalloproteinase-1，TIMP-1），B超及MR扩散加权成像（diffusion weighted imaging，DWI）。结果：B超与肝脏纤维化病理分级的相关系数为0.56，呈中等程度正相关，联合DWI、肝纤维化相关标志物及TIMP-1的非创伤性评估方法有高达84.69%正判率。结论：该联合评估方法是目前可操作性和可重复性好，值得推广的肝纤维化临床诊断方法之一。

Abstract:

Objective：To establish a joint non-invasive clinical method and system to assess and evaluate the severity of hepatic fibro－sis of patiants with non-alcoholic fatty liver disease（NAFLD）. Methods：Totally 104 patients with non-alcoholic fatty hepatic fibrosis were divided according to different histopathological stages.Hepatic fibrosis relation indexes，tissue inhibitors of matrix metallopro－teinase-1（TIMP-1），hepatic B ultrasond and liver diffusion weighted imaging（DWI）were detected. Results：There were consider－able correlations between hepatic ultrasond and liver fibrosis grading，with a correlation coefficient of 0.56. Joint non-invasive method combing DWI，liver fibrosis markers and TIMP-1 corrected 84.69% of all trials. Conclusions：This joint non-invasive assessment method is practical and repeatable and is recommended to be a clinical method for diagnosing liver fibrosis.