5-羟色胺2A受体基因多态性T102C与抑郁症关系的Meta分析研究

Meta analysis on the relationship between 5-hydroxytryptamine 2A receptor gene polymorphism T102C and depression

摘要:

目的：综合评价5-羟色胺（5-hydroxytryptamine，５-HT）2A受体基因多态性T102C与抑郁症的关系。方法：检索中国生物医学文献光盘数据库（CBMdisc）和PubMed（2000年1月至2012年11月）。根据纳入标准收集５-HT2A受体基因多态性与抑郁症研究的国内外文献。应用RevMan 5.0软件对符合条件的研究结果进行Meta分析。结果：共纳入9篇符合条件的文献，累计疾病组1 717例、对照组2 037例。数据合并结果显示５-HT2A受体基因多态性纯合子突变CC型、杂合子突变TC型与抑郁症并无明显关联。结论：５-HT2A受体基因多态性与T102C抑郁症并无明显关联，可能并不是抑郁症的易感因素。

Abstract:

Objective：To assess the association of 5-hydroxytryptamine（5-HT）2A receptor gene polymorphism with depression by Meta analysis. Methods：Literatures on the relationship between 5-HT2A receptor gene polymorphism T102C and depression in CBMdisc and PubMed from January 2000 to December 2012 were taken as research objects. Software of RevMan 5.0 was employed to do Meta analysis. Results：Nine literatures were included，enrolling 1 717 for depression and 2 037 for healthy controls. The results showed that there was no significant association between 5-HT2A receptor gene polymorphism and depression including the allele contrast model，homozygote model and heterozygotes genotypes. Conclusions：There is no significant association between 5-HT2A receptor gene polymorphism and depression，5-HT2A receptor single nucleotide polymorphism T102C may not confer the risk of depression as an independent risk factor.