Objective:To investigate the curative effect and postoperative complications of the third ventricle craniopharyngioma re-moved by transcallosal-stptum pellucidum-interforniceal approach. Methods:Clinical data of 28 patients with the third ventrile cran-iopharyngioma undergoing transcallosal-septum pellucidum-interforniceal approach resection were analyzed retrospectively. Results:Total tumor removal was achieved in 18 cases,subtotal removal in 6 cases and partial removal in 4 cases. Electrolyte disorder and diabetes insipidus were observed in most of the cases.Other frequent complications included endocrine disorders,mutism,hyperpyrexia and seizures. Conclusions:Transcallosal-septum pellucidum-interforniceal approach is the best choice for the resection of the third ventricle craniopharyngioma. Postoperative complication is common and serious,sufficient preoperative preparation and good periop-erative management is the premise of the successful operation.