miR-130a/b与肿瘤关系的研究进展

Progress in the relationship between miR-130a/b and tumor

摘要:

目的：总结国内外miR-130a和miR-130b在肿瘤学领域研究的现状。方法：应用PubMed和中国知网数据库检索系统，以“microRNA、miR-130a、miR-130b和肿瘤”等为关键词，联合检索1993-01—2013-12的相关文献。纳入标准：1）microRNA在肿瘤研究中的新进展；2）miR-130a；3）miR-130b；4）肿瘤。根据纳入标准，符合分析的文献47篇。结果：miR-130a和miR-130b是高度同源的microRNA，通过干扰靶mRNA转录或降解靶基因来调控基因表达，它们在不同的肿瘤中差异表达，并在多种肿瘤细胞的增殖、凋亡、转移和肿瘤耐药方面发挥着重要作用。结论：miR-130a/b在肿瘤发生发展中发挥促癌或抑癌的作用，其在肿瘤耐药方面的研究可以为多重耐药的患者提供新的视角。

Abstract:

Objective：To review the progress in the relationship between miR-130，miR-130b and tumor. Methods：Literatures pub－lished between January 1993 to December 2013 in Pubmed and CNKI data-base were searched using ‘microRNA，miR-130a，miR-130b and tumor’ as key words. Retrieval criteria：1）the progress of microRNA in tumor research；2）miR-130a；3）miR-130b；4） tumor. A total of 47 articles were included. Results：miR-130a and miR-130b were two highly homologous microRNAs，which regulated the expression of target genes through translational repression or mRNA degradation. The aberrant expression of miR-130a/b were involved in proliferation，apoptosis，metastasis and drug resistance of various tumor cells. Conclusions：miR-130a/b can act as oncogenes or tumor suppressors relating to the initiation and development of tumors，which may provide new perspective for the treatment of mul－tidrug resistance in tumors.