结直肠癌循环血游离miRs分子诊断标志物研究进展

Advance of colorectal cancer’ molecular diagnostic biomarkers-circulating free miRs

摘要:

微小RNAs（microRNAs，miRs）是一类非编码小分子单链RNA，主要在翻译水平负性调控基因表达。近年来研究发现，循环血游离miRs对结直肠癌（colorectal cancer，CRC）具有潜在的诊断作用。CRC患者具有特异性的循环血游离miRs表达谱，其中，miR-18a、miR-21、miR-29a和miR-92a等miRs均具有潜在的CRC诊断价值，而miR-7具有潜在的CRC早期诊断价值。这些研究结果表明，循环血游离miRs有可能成为新的CRC分子诊断标志物。

Abstract:

MicroRNAs（miRs） are noncoding small RNAs，being single strand in the mature form，which negatively regulate gene expression at the translational level. Recent studies have showed that circulating free miRs will probably play an important role in diagnosing colorectal cancer（CRC）. CRC patients have a specific expression profile of circulating free miRs，among which miR-18a，miR-21，miR-29a，and miR-92a have a potential di－agnostic value for CRC respectively. Moreover，miR-7 may distinguish patients of CRC at early stage from healthy individuals. These significant findings suggest that circulating free miRs are potential molecular diagnostic biomarkers of CRC.