TNF-β基因+252 A/G多态性与胃癌易感性Meta分析

A Meta analysis on the correlation between TNF-β gene +252 A/Gpolymorphism and susceptibility of gastric cancer

摘要:

目的：探讨肿瘤坏死因子（tumor necrosis factor，TNF）-β基因+252 A/G多态性与胃癌的发病相关性。方法：检索 Pubmed、Ovid、Springer、CBM、CNKI、万方数据库，时间从建库至2013年6月期间关于TNF-β基因+252 A/G多态性与胃癌发病相关性的病例-对照研究。根据纳入排出标准选择文献，提取资料，评价纳入研究质量，采用Review Manager 5.2及Stata 12.0软件进行Meta分析，亚组分型及敏感性分析评估其结果稳定性，并用Begg’s漏斗图和Egger’s回归图来评估发表偏倚。结果：共纳入了16篇病例对照研究，共计病例组2 538人，对照组3 908人。Meta分析结果显示：在各组遗传模型中，TNF-β基因+252 A/G多态性与胃癌发病无统计学意义：共显性遗传模型（G/G vs. A/A）：OR及95%CI：0.95（0.76，1.20）；显性遗传模型[（A/G+G/G） vs. A/A]：OR及95%CI：1.09（0.91，1.32）；隐性遗传模型[G/G vs. （A/G+A/A）]：OR及95%CI：0.88（0.72，1.07）；等位基因遗传模型（G vs. A）：OR及95%CI：1.00（0.90，1.11）（G/G、A/G、A/A分别代表基因型）。针对人种的亚组分析也无统计学意义。结论：TNF-β+252 A/G基因多态性与胃癌发病无明显相关性。本次结果受纳入研究质量及数量的限制，结论仍需进一步大规模研究验证。

Abstract:

Objective：To explore the relationship between tumor necrosis factor-β（TNF-β）gene +252 A/G polymorphism and suscep－tibility of gastric cancer. Methods：Case-control studies about TNF-β gene +252 A/G polymorphism and susceptibility of gastric cancer were searched from PubMed，Ovid，Springer，CBM，CNKI and Wan fang databases between establishment of databases and June 2013. According to the self-designed inclusion and exclusion criteria，data were extracted and quality of included studies was evaluated. Meta analysis was conducted by using Review Manager 5.2 and Stata 12.0 software with stability being evaluated by both stratified analysis and sensitivity analysis. Moreover，Begg’s funnel plot and Egger’s regression were used to assess the published bias of articles. Results：Sixteen case-control studies were included including 2 538 cases and 3 908 controls. Meta analysis showed that in each genetic model，no significant difference was found in the correlation between TNF-β gene +252 A/G polymorphism and gastric cancer：codominant genetic model（G/G vs. A/A）：OR and 95%CI：0.95（0.76，1.20）；dominant genetic model（（A/G+G/G） vs. A/A）：OR and 95%CI：1.09（0.91，1.32）；recessive genetic model（G/G vs. （A/G+A/A））：OR and 95%CI：0.88（0.72，1.07）；allele genetic model（G vs. A）：OR and 95%CI：1.00（0.90，1.11）.（G/G，G/A，A/A respectively represent the genotype）. There was no statis－tical significance in racial subgroup analysis. Conclusions：TNF-β +252 A/G polymorphism is not significantly related with gastric cancer. The conclusion is limited by the quality and number of included studies. Large-scale studies are needed in the further.