中枢神经系统水通道蛋白-4的功能研究进展

Recent advances in the function of aquaporin-4 in central nervous system

摘要:

水通道蛋白（aquaporin，ＡＱＰ）-4是中枢神经系统中含量最高的AQP，其主要作用是介导水的跨膜转运，既往对其研究主要集中在各种脑损伤后的脑水肿，而近年来却发现它还和中枢神经系统的其他许多功能和疾病相关，如神经再生、脑部炎症疾病等。因此，本文综述了近年来对AQP-4在中枢神经系统中的研究，以更新和加深对其认识，为将来把AQP-4作为治疗中枢神经系统疾病的靶点并开发针对性的药物提供新的思路。

Abstract:

Aquaporin-4（AQP-4） is the most abundant aquaporin in central nervous system（CNS）. Water movement cross cell mem－brane is mainly conducted by AQP-4. Previous studies of AQP-4 mainly focused on edema formation after various brain injuries，but recently AQP-4 has been found to connect with many other brain functions and diseases，such as regeneration and inflammation. Therefore，these researches were reviewed to renew current views on AQP-4 in CNS，hoping to provide new threads for the exploration of drugs against AQP-4.