轻微型肝性脑病患者静息态脑功能局部一致性研究

Regional homogeneity of resting-state brain activity in patients with minimal hepatic encephalopathy

摘要:

目的：探讨静息状态下轻微型肝性脑病（minimal hepatic encephalopathy，MHE）患者脑功能活动改变情况。方法：采用血氧水平依赖功能磁共振成像（blood oxygen level dependence-functional magnetic resonance imaging，BOLD-fMRI）技术，分析17例MHE患者（MHE组）和17例健康对照（healthy control，HC）组静息状态下脑功能活动差异；采用局部一致性（regional homo－geneity，ReHo）分析方法对数据进行处理。结果：与HC组相比，MHE组ReHo值降低的脑区包括右侧额内侧回、双侧前扣带回/额内侧回、右侧额下回、左侧直回/眶回、右侧丘脑及右侧小脑后叶（P＜0.005，校正后，cluster水平）；MHE组ReHo值升高的脑区包括左侧岛叶、右侧额中回/额下回及右侧梭状回/海马/海马旁回（P＜0.005，校正后，cluster水平）。结论：MHE患者表现为与多个认知调控环路相关的多个脑区神经元存在自发活动异常。

Abstract:

Objective：To study the resting-state brain activity in patients with minimal hepatic encephalopathy（MHE）. Methods： Sev－enteen patients with MHE and seventeen healthy control（HC） subjects underwent resting-state blood oxygen level dependence functional magnetic resonance imaging and the MRI data were analyzed with the regional homogeneity（ReHo） method. Results：Compared with HC group，MHE group showed lower ReHo in right medial frontal gyrus，bilateral anterior cingulate cortex/medial superior frontal gyrus，right inferior frontal gyrus，left rectal gyrus/orbital gyrus，right thalamus and right cerebellum posterior lobe，while higher ReHo in left insula，right middle frontal gyrus/inferior frontal gyrus and right fusiform gyrus/hippocampus/parahippocampa gyrus（P<0.005，cluster-level corrected）. Conclusion：Patients with MHE demonstrate abnormal neuron activities in multiple brain regions which are related with multiple cognitive control loops.