脉血康胶囊对糖尿病并短暂性脑缺血发作患者疗效及凝血功能的影响

Effects of Maixuekang capsule on therapeutic efficacy and blood coagulation function in patients with diabetes mellitus complicated with transient cerebral ischemic attack

摘要:

目的：观察脉血康胶囊对糖尿病并短暂性脑缺血发作（transisent ischemic attack，TIA）患者疗效及凝血功能的影响。方法：选择本院住院的80例TIA患者随机分为2组：对照组40例给予肠溶阿司匹林，脉血康组40例给予肠溶阿司匹林+脉血康胶囊，均连续治疗6个月。记录治疗6个月内TIA发作的症状、时间、次数；治疗6个月后检测颈动脉内膜中层厚度（intimal medial thickness，IMT）、凝血酶原时间（prothrombin time，PT）、活化部分凝血酶时间（activated partial thromboplastin time，APTT）、凝血酶时间（thrombin time，TT）、纤维蛋白原（fibrinogen，Fib）、血小板聚集率（platelet aggregation rate，PAR）、超敏-C反应蛋白（high sensitive C-reactive protein，hs-CRP）。结果：治疗6月后，脉血康组患者有效率显著高于对照组（χ2=4.266 6，P＜0.05），脉血康组患者脑梗死发病率显著低于对照组（χ2=4.504 5，P＜0.05）；脉血康组患者的PT、APTT、TT较治疗前和对照组显著延长（P＜0.05），Fib、PAR及hs-CRP较治疗前和对照组显著下降（P＜0.01）；２组患者的不良反应发生率无统计学差异（χ2=0.138 8，P ＞0.05）。结论：脉血康胶囊联合阿司匹林治疗糖尿病并TIA安全有效，抗凝、抗血小板聚集、抗炎可能是其作用机制之一。

Abstract:

Objective：To observe the effects of Maixuekang capsule on therapeutic efficacy and blood coagulation function in patients with diabetes mellitus complicated with transient cerebral ischemic attack（TIA）. Methods：Totally 80 patients with diabetes mellitus complicated with transient cerebral ischemic attack were divided into 2 groups randomly：40 patients in control group were given enteric-coated aspirin，40 patients in Maixuekang group were given enteric-coated aspirin + Maixuekang capsule. Patients received continuous treatment for three months. TIA attack symptoms，time，number of times within 6 months of treatment were recorded； Intimal medial thickness（IMT），prothrombin time（PT），activated partial thromboplastin time（APTT），thrombin time（TT），fibrinogen（Fib），platelet aggregation rate（PAR），high sensitive C-reactive protein（hs-CRP） at 6 months after the treatment were detected. Results：At 6 months after the treatment，total efficiency of Maixuekang group was significantly higher than that of the control group（ χ2=4.266 6，P＜0.05）. Incidence of cerebral infarction in Maixuekang group was significantly lower than that in the control group（ χ2=4.504 5，P＜0.05）. PT，APTT，TT of patients in Maixuekang group were significantly prolonged compared with those before the treatment and those in control group（P＜0.05）. Fib，PAR and hs-CRP were decreased significantly in Maixuekang group compared with those before the treatment and those in control group（P＜0.01）. There was no significant difference in the incidence of adverse reactions between two groups（ χ2=0.138 8，P ＞0.05）. Conclusions：Maixuekang capsule combined with aspirin is a safe and effective in the treatment of diabetes mellitus complicated with TIA，of which anticoagulation，anti-platelet aggregation and anti-inflammation may be one of the mechanisms.