H3N2甲型流感病毒与人类博卡病毒混合感染致塑型性支气管炎1例并文献复习
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Plastic bronchitis in influenza A(H3N2) and human bocavirus infection:a case report and literature review
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    摘要:

    目的:确诊塑型性支气管炎病例1例,总结其临床特点与病原学诊断。方法:患儿,5+岁,临床表现为发热、咳嗽、喘息、气促、进行性呼吸困难,胸部CT示左肺大片实变,肺不张可能,予以纤维支气管镜(纤支镜)检查及灌洗,取出气道内内生性异物,确诊为塑型性支气管炎。取该患儿支气管肺泡灌洗液进行16种呼吸道病毒检测。结果:患儿支气管肺泡灌洗液进行16种呼吸道病毒检测,甲型流感病毒检出阳性,进一步扩增病毒核蛋白段测序明确为H3N2;同时显示人类博卡病毒(human bo-cavirus,HBoV)检出阳性,病毒拷贝数为3×105 拷贝/ml。该例患儿取出内生性异物后治愈出院。结论:作为儿科危重症,塑型性支气管炎通过纤支镜检查与灌洗取出内生性异物,不仅可以明确诊断,也是必不可少的、有效的治疗方法,本例患儿支气管肺泡灌洗液病原学诊断结果提示流感病毒与HBoV混合感染,值得临床关注。

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    Objective:To summarize the clinical characteristics and to do etiological diagnosis for one confirmed case of plastic bronchitis. Methods:One child of more than 5 years old was enrolled. Clinical manifestations were fever,cough,gasp,anhelation and progressive difficulty of breath. Thoracic CT showed that the left lung had large parts of consolidation,possibly being pulmonary atelectasis. Bronchoscopy and lavage were conducted and the ingrown foreign body in the air passage being taken out. The child was diagnosed as plastic bronchitis. Bronchoalveolar lavage fluid of the sick child was taken out for detecting 16 kinds of respiratory viruses. Results:Detecting results of 16 kinds of respiratory viruses indicated that the sick child was influenza A virus positive,and the nucleoprotein sequencing of the further amplified virus was clarified as H3N2. At the same time,human bocavirus(HBoV) were found out and the number of virus copy was 3×105 copies/ml. The child was discharged from the hospital after the endogenous foreign matter being taken out. Conclusion:As a pediatric intensive case,plastic bronchitis can be clearly diagnosed by bronchoscopy and removing endogenous foreign body through lavage,which is essential for the effective treatment. The patient’s bronchoalveolar lavage etiological diagnosis remind us of mixed infection of human influenza viruses and HBoV,which is worthy of attention.

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何琳莉,邓 昱,耿 刚,罗 健,刘恩梅. H3N2甲型流感病毒与人类博卡病毒混合感染致塑型性支气管炎1例并文献复习[J].重庆医科大学学报,2014,38(7):995-997

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  • 在线发布日期: 2014-09-24
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