Objective:To discuss the efficacy of vitreoretinal surgery using 23-gauge transconjunctival sutureless vitrectomy(TSV) sys-tem for various vitreoretinal diseases. Methods:A total of 154 eyes of patients who underwent vitreoretinal procedures using 23-gauge minimally invasive surgery vitrectomy system in wide field retionscope were enrolled. Efficacy,intraoperative and postoperative compli-cations and operation time were observed. Moreover,intraocular pressure(IOP) and best corrected visual acuity(BCVA) of pre-and post-operation were determined. Results:①All operation were performed successfully. ②Mean duration of operation was (42.0±5.2) min(ranging from 28 min to 83 min). ③BCVA was improved at 1,2,3 months after operation compared with that before operation. ④Compared with those before operation,both lower and higher IOP were observed on 1 d after operation,higher IOP was observed on 3 d after operation and steady IOP was found on 7 d and 30 d after the operation. ⑤3 eyes(1.9%) had ocular hypotensipon af-ter operation,15 cases(9.7%) had ocular hypertension and no case of endophthalmitis was reported. Conclusion:With the advantages of shorter operation time,less trauma,fewer complications,more convenient and rapid visual recover,23-gauge TSV system is effec-tive in the treatment of vitreoretinal diseases.