超顺磁性Fe3O4壳聚糖纳米粒制备影响因素的初步研究

Influencing factors for preparation of superparamagnetic Fe3O4 chitosan nanoparticle

摘要:

目的：制备超顺磁性Fe3O4壳聚糖纳米粒，探究不同表面活性剂及交联剂等因素对纳米粒形成及其理化性质的影响。方法：化学共沉淀法制备纳米粒，激光粒度仪检测其粒径大小、聚合物分散指数（polydispersity index，PDI）、zeta电位，振动样品磁强计检测其磁化强度。结果：制备的纳米粒粒径大小在15～60 nm之间，平均粒径29.39 nm， PDI为0.185，zeta电位绝对值约20，磁感应性良好。结论：亲水亲油平衡值（hydrophile lipophilic balance，HLB）较小的表面活性剂能减小纳米粒粒径，交联剂戊二醛用量需控制在1.5～2.0 ml，NaOH溶液浓度需控制在3.0～4.0 mol/L。

Abstract:

Objective：To prepare superparamagnetic Fe3O4 chitosan nanoparticle and to explore the effects of different surfactants and crosslinkers on prepared nanoparticles. Methods：The nanoparticle was prepared by chemical co-precipitation method. The size，poly－dispersity index and zeta potential was detected by Zetasizer Nano. The magnetization intensity was detected by vibration sample magnetometer. Results：The size of the nanoparticle ranged from 15 nm to 60 nm，with an average size of 29.39 nm. Polydispersity in－dex was 0.185 and the absolute value of zeta potential of the nanoparticle was approximately 20. Magnetic induction was very well. Conclusion：The surfactants with low hydrophile lipophilic balance value can reduce the size of nanoparticle. Glutaraldehyde dosage should be controlled between 1.5 ml and 2.0 ml. Concentration of NaOH solution should be controlled between 3.0 mol/L and 4.0 mol/L.