增龄引起心房离子通道重构与房颤的关系

Association between atrial fibrillation and atrial ion channels remodeling induced by aging

摘要:

心房颤动（atrial fibrillation，AF），简称房颤，是临床上最为常见的快速性心律失常之一，尤其多见于老年人。年龄一直被认为是AF发生的重要危险因素之一。大量研究发现，心房重构（atrial remodeling，AR）是增龄性AF得以发生和维持的重要因素，心房肌细胞相关离子通道电流的变化及其通道蛋白、基因表达的变化在心房电重构（atrial electrial remodeling，AER）中起重要作用。本文就增龄引起心房离子通道重构与AF的关系予以综述。

Abstract:

Atrial fibrillation（AF） is one of the most common clinical tachyarrhythmia，which is seen most frequently in the elderly. Ag－ing is regarded as an important risk factor for AF. A lot of researchers find that atrial remodeling plays an important role in occurrence and maintenance of the age-related AF. The changes of ion channel currents and its channel protein or gene expression in atrial my－ocytes are related to occurrence of atrial remodeling. This paper made a review on the recent studies of the relationship between AF and the changes which leaded by aging in atrial remodeling and ion channels.