野生型p53基因的抑癌活性在肿瘤患者中常存在被抑制的现象。最新研究发现，p53的抑癌活性由p53凋亡刺激蛋白（apoptosis-stimulating protein of p53，ASPP）家族调控。该家族包含3个成员：p53凋亡抑制蛋白（inhibitory member of the apop－tosis-stimulating protein of p53，iASPP）、p53 ASPP1和p53 ASPP2。大量研究表明，iASPP是抑制p53活性和功能的重要因素，其表达和功能与肿瘤患者的临床表现、治疗效果和预后密切相关，在多种肿瘤的发生发展过程中发挥着重要的促进作用。通过本篇综述，作者期望对iASPP的特性和功能有较全面的了解，为今后以iASPP为靶点的抗肿瘤治疗提供新的思路。
Abstract:
The function of wild type p53 is usually inhibited in patients with tumor. The latest research showed that the function of wild type p53 was controlled by apoptosis-stimulating protein of p53（ASPP） family. ASPP family includes three members： iASPP，ASPP1 and ASPP2. Many studies showed that iASPP can inhibit the activity and function of p53；and its expression and function was correlated with clinical characteristics，curative effect and prognosis. It plays important roles in tumor development. In this review，we expect to explore the function and character of iASPP thus to provide a new way for the treatment of tumor using iASPP as target.
