β-TrCP在乳腺癌组织中的表达及其对患者预后的影响

Expression of β-TrCP in breast cancer tissues and its effect on prognosis of patients with breast cancer

摘要:

目的：探讨β-TrCP蛋白在乳腺癌组织中的表达及其对患者预后的影响。方法：采用免疫组化SP法检测56例乳腺癌及对应癌旁组织中β-TrCP蛋白表达情况，分析其表达与乳腺癌患者预后的关系。结果：β-TrCP蛋白在乳腺癌组织中的阳性率为71.4%（40/56），在对应癌旁组织中的阳性率为14.3%（8/56），差异具有统计学意义（χ2=37.333，P=0.000）；β-TrCP蛋白在乳腺癌组织中的阳性表达与雌激素受体阳性（P=0.002)、孕激素受体阳性（P=0.004)、淋巴结转移（P=0.007)和TNM分期（P=0.004）有关；β-TrCP阴性表达患者5年生存率100%（16/16），β-TrCP阳性表达患者5年生存率72.5%（29/40），95%CI=0.559～0.837。log-rank检验差异有统计学意义（P=0.015）。Cox多因素分析提示β-TrCP蛋白在乳腺癌组织中的阳性表达是乳腺癌患者预后不良的独立影响因素（RR=0.287，95%CI=0.120～0.683，P=0.005）。结论：β-TrCP蛋白在乳腺癌组织中的表达异常升高，且与乳腺癌患者不良预后相关，提示β-TrCP蛋白在乳腺癌发生发展中可能发挥重要作用。

Abstract:

Objective：To investigate the expression of β-TrCP in breast cancer tissues and its effect on prognosis of patients with breast cancer. Methods：β-TrCP expression in 56 samples of breast cancer and normal tissues and the corresponding samples of tumor-adjacent tissues were detected by immunohistochemistry. The correlation between β-TrCP expression and prognosis was analyzed. Results：The expression of β-TrCP in breast cancer tissues was significantly up-regulated compared with that of the normal tumor-ad－jacent tissues（χ2=37.333，P=0.000）. Clinicopathological evaluation suggested that β-TrCP positive expression was associated with ER positive（P=0.002），PR positive（P=0.004），lymph node metastasis（P=0.007） and TNM stage（P=0.004）. Five-year survival rate was 100%（16/16）in patients with negative expression of β-TrCP and was 72.5%（29/40）in patients with positive expression of β-TrCP（95%CI=0.559 to 0.837）. Results of log-rank test of statistical significance（P=0.015）. Multivariate Cox regression analysis revealed that β-TrCP positive expression was an independent factor for predicting poor prognosis in breast cancer（P=0.005，RR=0.287，95%CI=0.120-0.683）. Conclusion：High-expression of β-TrCP is correlated with the poor prognosis in breast cancer，suggesting β-TrCP may play a key role in development and progression of breast cancer.