血浆脑源性神经营养因子水平与抑郁症的相关性研究

Association of plasma brain-derived neurotrophic factor levels with depressive disorder

摘要:

目的： 探讨血浆脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）水平与抑郁症的相关性。方法：采用ELISA测定60例抑郁症患者和30名健康对照血浆BDNF的含量，并进行汉密尔顿焦虑量表（Hamilton depression rating scale，HDRS）和贝克抑郁自评量表（Beck self-rating depression scale，BDI）评定。结果：抑郁症组患者的血浆BDNF水平（931.10±250.04） pg/ml明显低于健康对照组（1 348.06±192.67） pg/ml（t=-8.013，P=0.000）。首发型抑郁症患者血浆BDNF水平（1 007.57±277.52） pg/ml高于复发型抑郁症患者（854.63±195.15） pg/ml（t=2.469，P=0.017）；早发型抑郁症患者与晚发型抑郁症患者HDRS得分（t=1.009，P=0.317）、BDI得分（t=1.743，P=0.087）以及BDNF水平（t=-0.281，P=0.779）之间差异无统计学意义；有自杀行为的抑郁症患者HDRS得分（t=3.917，P=0.000）和BDI得分（t=3.482，P=0.001）明显高于无自杀行为患者，而血浆BDNF水平（778.88±230.71） pg/ml明显低于无自杀行为的抑郁症患者（1 055.64±191.00） pg/ml（t=-5.085，P=0.000）；抑郁症患者血浆BDNF水平与HDRS得分（r=-0.337，P=0.008）和BDI得分（r=-0.431，P=0.001）之间呈负相关。结论：血浆BDNF水平的改变与抑郁症及自杀行为有关，可能参与了抑郁症和自杀行为的病理生理机制。

Abstract:

Objective：To explore the correlation between the plasma levels of brain-derived neurotrophic factor （BDNF） and depres－sion. Methods：Enzyme-linked immunosorbent analysis（ELISA） was used to test the plasma BDNF levels in 60 depressive patients and 30 normal controls. Meanwhile，the subjects were assessed with the Hamilton depression scale（HAMD） and Beck Self-rating De－pression Scale（BDI）. Results：The plasma levels of BDNF in depressive patients（931.10±250.04） pg/ml was significantly lower than those of normal controls（1 348.06±192.67） pg/ml（t=-8.013，P=0.000）. The plasma BDNF levels in recurrent depressive patients（1 007.57±277.52） pg/ml was lower than those of first-episode depressive patients（854.63±195.15） pg/ml（t=2.469，P=0.017）. There was no difference in HDRS total score（t=1.009，P=0.317），BDI total score（t=1.743，P=0.087） and plasma BDNF levels（t=-0.281，P=0.779） between early-onset depressive patients and late-onset depressive patients. Depressive patients with suicidal tendency had higher HDRS total score（t=3.917，P=0.000） and BDI total score（t=3.482，P=0.001） than depressive patients without suicidal tendency. The plasma BDNF levels were significantly lower in depressive patients with suicidal tendency than in depressive patients without sui－cidal tendency（（778.88±230.71） pg/ml vs. （1055.64±191.00） pg/ml，t=-5.085，P=0.000）. The plasma BDNF level was significant－ly negatively correlated with HDRS total score and BDI total score in depressive patients. Conclusion：The alteration of plasma BDNF level is related to depression and suicide，and it maybe involved in pathophysiology of depression and suicidal behavior.