骨形态发生蛋白在椎间盘退变修复中的作用机制研究进展

Research progresses of mechanism of bone morphogenetic proteins in the repairing of intervertebral discdegeneration

摘要:

椎间盘退变（intervertebral disc degeneration，IDD）主要见于腰椎间盘突出、椎管狭窄等疾病，其引起的肌肉劳损、腰背疼痛等症状严重困扰患者的正常生活。骨形态发生蛋白（bone morphogenetic proteins，BMPs）已被证实是一类与骨形成及软骨形成具有密切相关性的生长因子，在椎间盘组织的发展形成与功能维持中发挥的效应吸引了大量研究者探索其机理，而通过基因治疗的途径早期防治IDD是目前的研究热点之一，本文就BMPs在IDD修复过程中作用机制的研究进展进行综述。

Abstract:

Intervertebral disc degeneration（IDD） is mainly seen in the lumbar disc herniation，spinal stenosis and other spinal dis－eases and may cause symptoms like muscle strain and back pain，seriously bothering the normal lives of patients. Bone morphogenetic protein（BMP） is a kind of protein proven to be closely related with bone formation and cartilage formation. The effect of BMP on the development and function maintaining of intervertebral disc has attracted a large number of researchers to explore its mechanism. The preventive treatment of IDD by gene therapy is one of the current research hotspots. The research progresses of mechanism of BMP in the repairing of intervertebral disc degeneration were reviewed in this article.