Objective:To explore the feasibility of low power focused ultrasound in the treatment of hyperplasia of mammary glands. Methods:Twenty-one patients diagnosed as hyperplasia of mammary glands accepted low power focused ultrasound treatment,and re-ceived examination of breast ultrasonography or mammography. All patients were followed up separately for 1,3,6,12 months after the treatment. Results:Pain score of twenty-one patients was collected at 1,3,6,12 months after treatment. There were statistical differ-ences in pain score before and after the treatment(F=133.45,P=0.00). There was no statistical difference in thickness of hyperplasia gland between one month after the treatment and before the treatment(P=0.06) due to short time of follow-up. There were statistical differences in thickness of hyperplasia gland between 3,6,12 months after the treatment and before the treatment(F=10.9,P=0.00). Da-ta system grading of breast image reports decline in 13 patients(13-21,62%). Conclusion:It is effective to treat hyperplasia of mam-mary gland with low power focused ultrasound.