SLCO1B1基因521 T>C 多态性与他汀类药物对中国人群降脂疗效关系的系统评价

Association between SLCO1B1 521 T>C polymorphism and Statins effectiveness among Chinese population：a systematic analysis

摘要:

目的：探讨SLCO1B1基因521 T>C 多态性与他汀类药物对中国人群降脂疗效的关系。方法：计算机检索 PubMed、Web of Science、Embase、Cochrance Library、CNKI、WanFang Data、VIP。检索时间均从建库至2014年6月12日。采用非随机试验性研究的质量评价表进行质量评价。统计分析通过RevMan 5.2 和Stata 12.0软件实现。结果：共纳入5个研究，812名研究对象。SLCO1B1 基因 521 T>C 多态性与他汀降低中国人群血脂疗效相关性无统计学意义：显性遗传模型TC+CC vs. TT（MD=-0.38，95%CI=-1.91～1.14，P=0.62）、隐性遗传模型CC vs. TT+TC（MD=0.09，95%CI=-1.77～1.96，P=0.92）、加性遗传模型CC vs. TT（MD=-0.03，95%CI=-2.34～2.28，P=0.98）和TC vs. TT（MD=0.00，95%CI=-1.95～1.95，P=1.00）。结论：基于本文结果，尚不能认为 SLCO1B1 基因 521 T>C 多态性与他汀对中国人群降脂疗效有关联。期待今后针对中国人群开展更大样本、高质量的研究。

Abstract:

Objective：To evaluate the association between SLCO1B1 gene 521 T>C polymorphism and Statins effectiveness among Chinese population. Methods：Databases including PubMed，Web of Science，Embase，Cochrance Library，CNKI，WanFang Data and VIP were searched to retrieve the relevant references from the start to June 2014. A quality assessment was performed using the Methodological Index for Non-Randomized Studies（MINORS） criteria. Meta-analysis，sensitivity analysis（Revman 5.2），publication bias measuring were all done（Stata 12.0）. Results：A total of 5 studies were included for final meta-analysis，involving 812 partici－pants. Overall，there was no statistically significant association for the four genetic models of hypolipidemic effect. The dominant ge－netic model TC + CC vs. TT（MD=-0.38，95%CI=-1.91 to 1.14，P=0.62），recessive model CC vs. TT + TC（MD=0.09，95%CI=-1.77 to 1.96，P=0.92），the additive genetic model CC vs. TT（MD=-0.03，95%CI=-2.34 to 2.28，P=0.98） and TC vs. TT（MD=0.00，95%CI= -1.95 to 1.95，P=1.00）. Conclusion：There is no association between SLCO1B1 521 T>C polymorphism and Statins effectiveness among Chinese population.