过氧化物酶体增殖物激活受体β在中枢神经系统疾病中的作用

Effects of PPARβ in central nervous system diseases

摘要:

过氧化物酶体增殖物激活受体（peroxisome proliferator activated receptors，PPARs）是一类核受体超家族，其成员有PPARα、PPARβ（也称为PPARδ）和PPARγ 3种亚型。PPARs自被发现以来受到广泛关注并在各个领域展开研究，其中主要集中在PPARα和PPARγ的研究上，对其在体内的病理生理作用都有了比较深刻的了解，其部分配体也已广泛用于临床治疗，而对PPARβ的研究相对较少。近来有学者认为PPARβ是PPARα和PPARγ激活的连接枢纽，使得其地位更加重要，PPARβ在中枢神经系统疾病中的作用及其调控机制越来越引起人们的关注。但关于PPARβ在中枢神经系统疾病中的作用及机制的研究却远落后于其他2种亚型。本文就PPARβ在中枢神经系统疾病中的作用进行综述。

Abstract:

Peroxisome proliferator activated receptors（PPARs） are a class of nuclear receptor superfamily，which is consisted of PPA－Rα，PPARβ（also named PPARδ） and PPARγ. PPARs has been widely concerned and studied in every field since its discovery. The most studies focused on PPARα and PPARγ. Their physiopathological effects in vivo have been profoundly understood，and some of their ligands have been widely used in clinical treatment. However，there were fewer studies about PPARβ. Recently，it is believed that PPARβ is a connection hub of PPARα and PPARγ，making PPARβ more important. An increasing concern was paid on the role and regulation mechanism of PPARβ in central nervous system diseases，however，the researcheson PPARβ were far behind those on PPARα and PPARγ. This article reviews the role of PPARβ in central nervous system diseases.