偏头痛与代谢综合征的相关性研究

Correlation between migraine and metabolic syndrome

摘要:

目的：探讨偏头痛临床特点与代谢综合征（metabolic syndrome，MS）及其各组分之间的相关性。方法：对212例就诊于我院神经内科门诊的偏头痛患者进行问卷调查，记录头痛特点及合并症，利用人体测量学、血液生化明确MS的诊断，经颅多普勒超声测量颅内血管功能。结果：212例偏头痛患者中，145例（68.4%）合并一种或多种代谢异常，22例（10.4%） 合并MS。单因素分析显示偏头痛患者中，年龄、头痛持续时间、体质指数、腰臀比与代谢异常的发生有一定的关联（P值分别为0.007、0.008、0.00０、0.00０）。多因素logistic回归分析显示过度使用止痛药是偏头痛患者发生MS的主要危险因素（OR=4.320，P=0.042）。结论：偏头痛合并MS与过度使用止痛药有关，合理使用止痛药可能降低偏头痛患者发生MS及心血管疾病的风险。

Abstract:

Objective：To investigate the correlation of clinical characteristics of migraine with metabolic syndrome（MS） and its com－ponents. Methods：Totally 212 migraineurs were recruited in the neurology clinic department. A questionnaire survey was used to col－lect the clinical characteristics of migraine headache and its concomitants，such as analgesic use，psychiatric disorders and disability. The anthropometric measurements and blood biochemistry were measured for the diagnosis of MS，and Transcranial Doppler sonography was conducted for intracranial vascular function. Results：Of 212 migraine patients，145 cases（68.4%） had one and more metabolic abnormalities and 22 cases（10.4%） had MS. Single factor analysis results showed metabolic abnormalities in migraine patients were associated with age，duration of migraine attack，body mass index and waist-to-height ratio（P=0.007，0.008，0.000 and 0.000，respective－ly）. Multivariate logistic regression analysis showed analgesic-overuse was the main risk factor of MS in migraine patients（OR=4.320，P=0.042）. Conclusion：The prevalence of MS in migraine patients is associated with analgesic-overuse. Rational use of analgesics may lower the risk for MS and cardiovascular disease in migraine patients.