早期胃癌分化程度与临床病理因素的相关性分析

Correlation between differentiation degree of early gastric cancer and clinical pathologial factors

摘要:

目的：探讨早期胃癌分化程度的影响因素，为选择合适的治疗方案提供依据。方法：收集重庆医科大学附属第一医院2009年1月到2014年1月行胃癌D2根治术病例，早期胃癌占11%（97/852），选97例早期胃癌资料行回顾性分析。对患者的肿瘤大小、大体类型、肿瘤部位、浸润深度、淋巴结转移、肿瘤标志物、血行转移、性别、年龄与分化程度的关系进行单因素及多因素分析。结果：97例早期胃癌中，未分化型为73%（70/97）。logistic回归多因素分析结果显示：患者女性、年龄小于50岁及胃下1/3部位为未分化型的危险因素（P<0.05），OR值、95%CI及P值分别为（4.9、13.7、3.4）、（2.4～13.6、4.2～24.1、1.7～8.4）、（0.019、0.013、0.027）。肿瘤大小、浸润深度、大体类型、淋巴结转移是否与未分化型腺癌无相关性。结论：早期胃癌的分化程度主要与患者的性别、年龄及肿瘤部位有关。

Abstract:

Objective：To investigate the influencing factors of differentiation degree of early gastric cancer（EGC） and to provide theo－retical basis clinically. Methods：The clinical data of gastric cancer patients with D2 lymph node dissection who underwent surgery in the First Affiliated Hospital of Chongqing Medical University from January 2009 to January 2014 were collected. The clinical data of 97 early gastric cancer patients were retrospectively analyzed. Tumor size，general type，tumor location，depth of invasion，lymph node metastasis，tumor markers，blood line transfer，gender，age and differentiation degree were analyzed using single factor and multiple factors analysis. Results：Logistic regression analysis showed that the undifferentiated carcinoma accounted for 73%（70/97）. Multiple analysis showed that female，<50 years old，1/3 part under the stomach were highly related to undiferentiated carcinoma（P<0.05）； OR，95%CI and P were（4.9，13.7，3.4），（2.4-13.6，4.2-24.1，1.7-8.4） and （0.019，0.013，0.027，respectively. However，there was no correlation between patients’ tumor size，general type，depth of invasion，lymph node metastasis，etc with undiferentiated carcinoma. Conclusion：The degree of differentiation in early gastric cancer has been proved to be mainly correlated with the gender，age，and tu－mor location.