超脉冲CO2激光治疗儿童化脓性肉芽肿的临床疗效观察

Clinical efficacy of ultra-pulse CO2 laser in the treatment of the children’s pyogenic granuloma

摘要:

目的：观察超脉冲 CO2激光治疗儿童化脓性肉芽肿的临床疗效及安全性。方法：重庆医科大学附属儿童医院皮肤科门诊2011年收治化脓性肉芽肿患儿120例，采用普通CO2激光治疗，作为对照组；2012年收治化脓性肉芽肿患儿103例，采用超脉冲CO2激光治疗，作为治疗组。2组均遵循患者本人或家长自愿原则，激光术后1个月、3个月、6个月、1年复诊，评估治疗效果及不良反应。结果：治疗组有效率为97.1%，对照组有效率为96.7%，对照组与治疗组治疗有效率比较差异无统计学意义（P >0.05）。对照组120例共计26例（22.0%）有不良反应，其中轻微疤痕14例，色素沉着5例，色素减退4例，红斑3例。治疗组103例共计10例（9.7%）有不良反应，其中轻微疤痕3例，色素沉着3例，色素减退2例，红斑2例。对照组出现不良反应概率明显大于治疗组。2组治疗不良反应发生率差异有统计学意义（P<0.05）。结论：超脉冲CO2激光治疗化脓性肉芽肿具有较好的临床疗效，不良反应发生低。

Abstract:

Objective：To observe the clinical efficacy and the adverse effects of ultra-pulse CO2 laser in the treatment of the children’s pyogenic granuloma. Methods：Following the voluntary principle，the 120 patients with pyogenic granuloma were treated by traditional CO2 laser as control group；the 103 patients with pyogenic granuloma were treated by ultra-pulse CO2 laser as treated group. Accord－ing to the voluntary principle，the treatment effect and the adverse effects were evaluated at 1 month，3 months，6 months，12 months postoperatively. Results：The effective rate in the treatment group was 97.1%，while that in the control group was 96.7%，without sig－nificant differences between two groups（P >0.05）. Among 120 cases in the control group，26 cases had adverse effects，including mild scar（14 cases），pigmentation（5 cases），pigment loss（4 cases），and erythema（3 cases）. Among 103 cases in the treatment group，10 cases had adverse effects，including mild scar（3 cases），pigmentation（3 cases），pigment loss（2 cases），and erythema（2 cases）. The incidence of adverse effects between two groups had significant differences（P<0.05）. Conclusion：Application of the ultra-pulse CO2 laser in treatment of the pyogenic granuloma has better clinical efficacy，with good safety profile than the traditional treatment.