microRNA与结核病相互关系的研究进展

Research progress in relationship of microRNA with tuberculosis

摘要:

microRNA（miRNA）是一类广泛存在于各种生物体内的小分子非编码单链RNA，主要在转录后水平调控靶基因的表达。越来越多的证据表明它在细胞分化与沟通、机体发育、免疫反应等诸多方面都发挥着重要作用。尤其在疾病相关研究中，miRNA更是具有广泛的用途和美好的前景。本文主要针对miRNA的相关特性、与结核病（tuberculosis，TB）相互关系的研究进展以及应用前景等做综述。

Abstract:

microRNAs（miRNAs） were a group of single strand non-coding RNAs wildly spread in animals，plants and virus. Accumu－lating evidence revealed the function of miRNA in cell differentiation，cell cross talking，development，immune defense，especially in the prospect of disease diagnosis and therapy. In this article，we reviewed the research progress of miRNA，including the structure，the relationship between tuberculosis（TB） and application prospects.