金黄色葡萄球菌表面蛋白质SdrE的研究现状

Surface protein SdrE from Staphylococcus aureus

摘要:

金黄色葡萄球菌（Staphylococcus aureus，S.aureus）是常见致病菌，其表面蛋白质在感染宿主过程中发挥重要作用，其中SdrE蛋白质为其表面蛋白质之一，研究发现 SdrE蛋白质的表达几乎不受环境因素（包括温度、金属离子）的影响，并且可能与S.aureus对甲氧西林的抵抗力有关，近年来发现SdrE蛋白质的磷酸化直接影响了S.aureus的毒性，同时，SdrE蛋白质能够通过黏附补体调节因子H来逃避宿主免疫反应，并且还能够独立诱导血小板发生聚集，已经发现SdrE蛋白质能够在骨骼感染、关节感染以及骨髓炎中发挥重要作用。本文主要分析了SdrE蛋白质的生物学功能，为基于SdrE蛋白质的新的特异性抗菌药物的开发指明方向和提供理论基础。

Abstract:

Staphylococcus aureus（S.aureus） is a common pathogen and its surface proteins play an important role in the process of infected host. The SdrE protein，the expression of which is almost free from environmental factors（temperature，metal ions），is one of the S.aureus surface proteins and may associate with S.aureus resistance to methicillin. Recently，researchers have found that phosphorylation of SdrE directly affects the toxicity of S.aureus，and SdrE can evade the host immune response by adhesion complement regulatory factor H，as well as induce platelet aggregation independently. In addition，SdrE protein has been found to play a vital role in bone infections，joint infections and osteomyelitis. This review analyzed the biological functions of SdrE，and provided a theoretical basis for the development of new specific antibacterial agents.