ABCA1基因R1587K多态性与冠心病遗传易感性的系统评价

Association between ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility：a systematic review

摘要:

目的：探讨三磷酸腺苷结合盒转运蛋白A1（ATP binding casette transporter A1，ABCA1）基因R1587K多态性与冠状动脉粥样硬化性心脏病（coronary heart disease，CHD）遗传易感性的关系。方法：计算机检索PubMed、Web of Science、中国学术期刊全文数据库（CNKI）、万方数据库和维普数据库，检索时间截止2014年7月，获取有关ABCA1基因R1587K多态性与冠心病遗传易感性的病例-对照研究。以OR 值及其95%CI为效应指标，运用Stata 11.0软件在异质、同质、显性和隐性遗传模式下进行Meta分析。结果：共纳入5个研究（实验组2 032例和对照11 492例）。Meta分析结果显示ABCA1基因R1587K多态性与冠心病遗传易感性在异质和显性遗传模式下均存在明显的统计学意义（异质模式：OR=1.140，95%CI=1.028~1.266，POR=0.014；显性模式：OR=1.124，95%CI=1.017~1.243，POR=0.022）；按种族进行亚组分析其结果显示该遗传易感性在高加索人群中较显著。结论：ABCA1基因R1587K多态性可能与高加索人群冠心病遗传易感性有关，需开展更多高质量、大样本的随机对照试验加以验证。

Abstract:

Objective：To investigate the association between ATP binding casette transporter A1（ABCA1） gene R1587K polymorphism and coronary heart disease susceptibility. Methods：Literature was retrieved in electronic databases covering PubMed，Web of Science，CNKI，WanFang and VIP up to Jun，2014 to collect the case-control studies on ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility. The odds ratios（ORs） and 95% conidence intervals（CIs） were taken as the effect indexes，either the fixed or random effect model was applied to conduct Meta-analysis by Stata 11.0 software in heterozygote，homozygote，dominant，and recessive genetic models，respectively. Results：A total of 5 case-control studies were identified，involving 2 032 cases and 11 492 controls. The current Meta-analysis showed that the AB－CA1 gene R1587K polymorphism was significantly associated with coronary heart disease under homozygote and dominant genetic model（homozygote：OR=1.140，95%CI=1.028~1.266，POR=0.014；dominant：OR=1.124，95%CI=1.017~1.243，POR=0.022）. Subgroup analysis results by ethnicity were significantly associated with Caucasian. Conclusion：The current Meta-analysis suggests that ABCA1 gene R1587K polymorphism might be associated with coronary heart disease susceptibility in Asian. Further studies are needed to val－idate the above conclusion.