伴自杀意念抑郁症患者事件相关电位的研究

Study of event-related potentials of non-treatment major depressive disorder patients with suicidal ideation

摘要:

目的：运用事件相关电位方法探讨伴自杀意念抑郁症患者事件相关电位的特征。方法：在重庆医科大学附属第一医院心理卫生中心按照一定的纳入和排除标准募集伴自杀意念抑郁症患者，记录既往未曾治疗的20例伴自杀意念抑郁症患者执行情绪Stroop任务时诱发的事件相关电位（event-related potent, ERP）。结果：伴自杀意念抑郁症患者整体平均反应时间为（695.04±2.16） ms，不同词-面孔Stroop反应时间的差异有统计学意义（P<0.05）；伴自杀意念抑郁症患者ERP相关成分P1、N1、P2、P3的潜伏期在4种不同的词-面孔干扰下，差异无统计学意义（P>0.05）；ERP相关成分N1、P2、P3的波幅在4种不同的词-面孔干扰下，差异有统计学意义（P<0.05）。结论：伴自杀意念抑郁症患者在不同情绪面孔刺激下存在不同程度的注意偏向和认知功能差异。

Abstract:

Objective：To explore the characteristics of event-related potential of MDD（major depressive disorder） patients with suici－dal ideation. Methods：We collected MDD patients with suicidal ideation by certain inclusive and exclusive criterias in Mental Health Center，the First Affiliated Hospital of Chongqing Medical University，and recorded the event-related potent（ERP） of 20 non-treatment MDD patients with suicidal ideation when executing emotional stroop mission. Results：The total average reaction time of MDD patients with suicidal ideation was （695.04±2.16） ms；the reaction time was statistical significant between the different word-facial tasks（P<0.05）；there is no statistical significance in the latentperiodofERP related components：P1，N1，P2，P3 of MDD patients with suicidal ideation under four words-facial interference.There were statistical significancesin the amplitude of ERP related components：N1，P2，P3，which under four words-facial interference. Conclusion：Attentional bias and cognitive function differences existed in different emotional-facial stimulus for MDD patients with suici－dal ideation.