转化生长因子β及骨形成蛋白通路调节肺动脉血管平滑肌细胞异常增殖

Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells

摘要:

转化生长因子-β（transforming growth factor-β，TGF-β）超家族由多种细胞因子组成，主要的配体分为TGF-β和骨形成蛋白（bone morphogenetic protein，BMPs）两类。近年来发现，TGF-β和BMPs刺激调节肺血管平滑肌的增殖，相互之间存在拮抗，表现为Smads依赖和Smads不依赖2种方式；个体基因的变异可能导致TGF-β和BMPs对肺血管平滑肌细胞增殖产生不同甚至相反的效应。本文就转化生长因子-β及骨形成蛋白通路调节肺动脉血管平滑肌细胞异常增殖进行综述。

Abstract:

The transforming growth factor-β（TGF-β） superfamily is composed of many cytokines，mainly including of TGF-βs and bone morphogenetic proteins（BMPs）. Recently，antagonism effect between TGF-βs and BMPs on proliferation in pulmonary artery smooth muscle cells is showed. Furthermore，individual genes variation might cause to different，even opposite effects of TGF-βs or BMPs on the proliferation. This article reviewed the regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pul－monary artery smooth muscle cells.