七氟烷对缺血再灌注心肌的保护作用

Protective effects of sevoflurane on myocardial ischemia reperfusion injury

摘要:

大量研究表明，七氟烷预处理和后处理，在心肌缺血再灌注中起到了心肌保护作用，而关于其作用机制，相关研究和争议颇多。本文就七氟烷在心肌缺血再灌注中的保护作用作一综述，为临床麻醉用药提供指导。同时指出七氟烷心肌保护作用在临床工作中所遇到的问题，并提出对未来研究的展望。

Abstract:

Large amounts of experiments have proved that sevoflurane，both preconditioning and post-conditioning，has the cardio-protective effect. However，the specific mechanism of this effect has been studied a lot and is greatly disputed. This article reviews these mechanisms in the cardio-protective effect of sevoflurane. Meanwhile，theoretical bases for rational administration of sevoflurane during clinical anesthesia are provided. The application and its limitations of the cardio-protective effect of sevoflurane in the current clinical work，along with our expectations are also put forward.