Objective:To investigate the efficacy and safety of flexible ureteroscopy lithotripsy without preoperative stent placement in the treatment of upper urinary tract calculi. Methods:The clinical data of 269 patients who were scheduled for flexible ureteroscopy lithotripsy without preoperative stent placement from November 2016 to September 2017 in our department were analyzed retrospec-tively. Results:The success rate of operation was 89.6%,while the mean operation time was 40.3 min. The complication rate was 6.2%,and the stone-free rate was 92.5%. Conclusion:Flexible ureteroscopy lithotripsy without preoperative stent placement is safe and effective,and it can decrease the medical cost,so it is worthy to be promoted.