老年局部晚期食管癌的研究进展

Research progress of locally advanced esophageal cancer in the elderly

摘要:

食管癌发病率及死亡率一直位居全球恶性肿瘤前列，并且老年患者所占比例大。目前以手术为主的综合治疗是局部晚期食管癌主要治疗模式，然而老年患者生理储备功能下降，常合并多种慢性疾病，因此经常被临床试验排除在外，治疗的选择缺乏数据支持并存在争议。当前靶向治疗尚未取得令人满意的结果，但免疫治疗前景值得期待。当然，在关注治疗的同时，营养支持治疗也应得到更多注意。本文就老年局部晚期食管癌的研究进展进行综述，旨在为其治疗决策的选择提供参考。

Abstract:

The incidence and mortality of esophageal cancer have been among the highest in the world of and elderly patients account for the great proportion. At present，the main treatment for locally advanced esophageal cancer is surgery. However，the elderly patients，with decreased physiological function and a variety of chronic diseases，have often been excluded from clinical trials. Current targeted therapies have not yielded satisfactory results，but the prospects for immunotherapy are worth the wait. Of course，while paying attention to treatment，nutrition support should receive more attention. This review summarizes the current research status and progress of elderly locally advanced esophageal cancer in order to provide reference for the choice of treatment decision.