Klotho与糖尿病及糖尿病肾病的研究进展

Klotho on diabetes mellitus and diabetic nephropathy

摘要:

Klotho基因是一种抗衰老基因，在体内有广泛表达，具有抗炎、抗氧化、抗凋亡等作用。近年研究显示，Klotho表达水平下降与糖尿病及糖尿病肾病的病理进展相关，过表达Klotho基因或给予外源性Klotho蛋白则具有明显改善作用。同时Klotho可能通过对内皮素-1对乙型糖尿病患者的血管病变产生影响。这些结果提示Klotho可望成为糖尿病的重要治疗靶点。

Abstract:

Klotho gene is a widely expressed anti-aging gene，with functions of anti-inflammatory，anti-oxidation，anti-apoptosis，etc. In recent years，studies have shown that decreased level of Klotho expression is associated with pathologic progression of diabetes and diabetic nephropathy，which can be improved by overexpressing Klotho or adding exogenous Klotho protein. Moreover，Klotho may have an effect on vasculopathy in patients with T2DM by endothelin-1. Therefore，Klotho may become an important therapeutic target for diabetes.