2型糖尿病患者血清锌α2糖蛋白与血脂的相关性

Correlation between serum Zinc-α2-glycoproteins level and serum lipids in type 2 diabetes mellitus

摘要:

目的：探讨2型糖尿病（type 2 diabetes mellitus，T2DM）患者血清锌α2糖蛋白（Zinc-α2-glycoproteins，ZAG）与血脂的相关性。方法：选取新诊断T2DM患者90例与正常健康者87例，记录一般临床指标；收集所有受试者的空腹血清标本，酶法测定血脂水平，ELISA法检测血清ZAG水平，Pearson相关和多元逐步回归分析ZAG与血脂的相关性。结果：与对照组相比，T2DM组血清ZAG水平降低[（59.69±12.97） vs. （36.07±12.15） mg/L，P=0.000]，非超重T2DM组和超重T2DM组血清ZAG水平均降低[（60.95±13.05） vs. （38.93±10.59） mg/L，P=0.000；（56.36±12.42） vs. （33.78±12.92） mg/L，P=0.000]。相关性分析和多元逐步回归分析显示T2DM组空腹血清ZAG与HDL-C（r=0.345，P=0.001）、BMI（r=-0.330，P=0.002）、HOMA-IR（r=-0.290，P=0.006）相关。以HDL-C=1.04 mmol/L分层分析显示T2DM患者HDL-C≥1.04组较HDL-C＜1.04组的血清ZAG水平升高[（38.01±12.62） vs. （30.75±9.00） mg/L，P=0.011]；对照组空腹血清ZAG水平与TC呈正相关（r=0.292，P=0.006），以TC=5.18 mmol/L为切点进行分层分析发现对照组中TC≥5.18组较TC＜5.18组的血清ZAG水平升高[（63.36±12.03） vs. （56.97±13.09） mg/L，P=0.022]。结论：脂肪细胞因子ZAG可能与T2DM脂代谢紊乱过程有关，并且ZAG对促进脂代谢稳态可能具有有利作用。

Abstract:

Objective：To investigate the relationship between serum Zinc-α2-glycoproteins（ZAG） level and serum lipids in type 2 diabetes mellitus（T2DM）. Methods：Ninety newly diagnosed T2DM patients and eighty-seven healthy people were enrolled in the study. General clinical indices were recorded and fasting serum samples were collected from all subjects，serum lipids levels were mea－sured by enzymatic methods. Serum ZAG level was measured by ELISA. The relationship between ZAG and serum lipids were ana－lyzed by Pearson correlation analysis and multiple stepwise regression analysis. Results：The level of serum ZAG in patients with T2DM was lower than that of control group[（59.69±12.97） vs. （36.07±12.15） mg/L，P=0.000]，the level of fasting serum ZAG was lower in both non overweight T2DM group and overweight group[（60.95±13.05） vs. （38.93±10.59） mg/L，P=0.000；（56.36±12.42） vs. （33.78±12.92） mg/L，P=0.000]. The fasting serum ZAG level was correlated with HDL-C（r=0.345，P=0.001），BMI（r=-0.330，P=0.002），HOMA-IR（r=-0.290，P=0.006） in T2DM group，and serum ZAG levelin HDL-C≥1.04 group were higher than that of HDL-C＜1.04 group by hierarchical analysis with the cut-off value of HDL-C=1.04 mmol/L[（38.01±12.62） vs. （30.75±9.00） mg/L，P=0.011]；Whereas the fasting serum ZAG level was positively correlated with TC in control group（r=0.292，P=0.006），the serum ZAG levelin the TC≥5.18 group was higher than that of TC<5.18 group by hierarchical analysis with the cut-off value of TC=5.18 mmol/L[（63.36±12.03） vs. （56.97±13.09） mg/L，P=0.022]. Conclusion：The adipocyte factor ZAG may be correlated with the process of lipid metabolism disorder in T2DM，serum ZAG may play a beneficial role in promoting homeostasis of lipid metabolism.